The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6452-8. doi: 10.1016/j.bmcl.2009.09.027. Epub 2009 Sep 12.

Abstract

Optimisation of a series of benzazepine sulfonamide hit compounds identified from high throughput screening led to the discovery of a new series of tractable, potent motilin receptor agonists.

MeSH terms

  • Animals
  • Binding Sites
  • CHO Cells
  • Chemistry, Pharmaceutical
  • Cricetinae
  • Cricetulus
  • Drug Design
  • Drug Discovery
  • Models, Chemical
  • Molecular Structure
  • Receptors, Gastrointestinal Hormone / agonists*
  • Receptors, Neuropeptide / agonists*
  • Structure-Activity Relationship
  • Sulfonamides / pharmacology*
  • Sulfones / pharmacology*

Substances

  • Receptors, Gastrointestinal Hormone
  • Receptors, Neuropeptide
  • Sulfonamides
  • Sulfones
  • motilin receptor